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Activity of Single Protein May Enable Alternatives to Insulin for Diabetes Therapy

Patients with a severe form of diabetes in which pancreatic beta cells produce insufficient, or even no insulin have must inject themselves regularly with artificial insulin to survive. Insulin therapy, which celebrated its 100th anniversary in 2021, has probably saved the lives of hundreds of millions of people with either type 1 diabetes (T1D) or with severe forms of type 2 diabetes (T2D). However, insulin therapy is not without risks if the doses are too high or too low, and in the long term, it can also lead to serious metabolic and cardiovascular problems, and even directly be responsible for some potentially fatal conditions.


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